Chaotropes and denaturants (urea, GdnHCl)
16 listings from 9 suppliers · 2 Japanese makers
Japanese name: カオトロープ・変性剤（尿素・塩酸グアニジン）
Urea and guanidine hydrochloride are bulk chaotropic reagents that solubilize and denature proteins. In manufacturing they dissolve inclusion bodies, for example from E. coli, as the first step before refolding. Buyers should confirm whether a grade is controlled for microbial and endotoxin levels when it will be used in a production process. Guanidine hydrochloride and urea products are listed, including pharmacopoeia-compliant and biopharma grades.
| Product | Maker | Where to buy in Japan |
|---|---|---|
| Guanidine hydrochloride (biochemistry grade, G3272 series) | Merck | Merck Ltd., Japan (Japanese subsidiary, Life Science) |
| Guanidine hydrochloride EMPROVE EVOLVE | Merck | Merck Ltd., Japan (Japanese subsidiary, Life Science) |
| Guanidinium chloride EMPROVE Expert | Merck | Merck Ltd., Japan (Japanese subsidiary, Life Science) |
| UltraPure Guanidine Hydrochloride | Thermo Fisher Scientific | Thermo Fisher Scientific K.K. (Japanese subsidiary) |
| Guanidine Hydrochloride, >99.5%, Molecular Biology Grade | Thermo Fisher Scientific | Thermo Fisher Scientific K.K. (Japanese subsidiary) |
| Guanidine hydrochloride (for molecular biology) | FUJIFILM WakoJP maker | From the maker |
| Guanidine hydrochloride for biochemical research | Nacalai TesqueJP maker | From the maker |
| Guanidine Hydrochloride, Ultra Pure grade (≥99%) | MP Biomedicals | Not yet confirmed |
| Guanidine HCl | GoldBio | Not yet confirmed |
| Guanidinium hydrochloride ≥99%, Ultrapure | VWR | Not yet confirmed |
| Product | Maker | Where to buy in Japan |
|---|---|---|
| Urea, BioReagent (U5378) | Merck | Merck Ltd., Japan (Japanese subsidiary, Life Science) |
| Urea puriss. (Ph. Eur./BP/USP compliant, 15604) | Merck | Merck Ltd., Japan (Japanese subsidiary, Life Science) |
| Urea, ≥99.5%, Molecular Biology Grade, Ultrapure (J75826) | Thermo Fisher Scientific | Thermo Fisher Scientific K.K. (Japanese subsidiary) |
| Urea, BioReagent (Honeywell Fluka) | Honeywell | Not yet confirmed |
| Urea (electrophoresis grade, #1610745) | Bio-Rad | Bio-Rad Laboratories K.K. (Japanese subsidiary) |
| Urea (for biochemistry) | FUJIFILM WakoJP maker | From the maker |
“Where to buy in Japan” shows only sales relationships we have confirmed on the company’s or the distributor’s own website. “Not yet confirmed” means we have not checked yet, not that the product is unavailable in Japan. Product names link to the maker’s own page.