Peptide mapping proteases are MS-grade digestion enzymes, such as trypsin and Lys-C, that cut an antibody at specific residues before LC-MS analysis. They are used to confirm primary structure and analyze post-translational modifications. Buyers compare MS grade, meaning suppressed autolysis and nonspecific cleavage, cleavage specificity, and what to add to trypsin: complementary proteases, Lys-C mixtures that reduce missed cleavages, or subunit enzymes. Immobilized and automated kits also exist. Makers and products we track are listed below, along with the Japanese company that sells each.
“Where to buy in Japan” shows only sales relationships we have confirmed on the company’s or the distributor’s own website. “Not yet confirmed” means we have not checked yet, not that the product is unavailable in Japan. Product names link to the maker’s own page.